Mohs micrographic surgery is a specialized method to remove skin cancer. It is named in honor of Frederick Mohs, the physician who developed the technique.Mohs surgery differs from other methods of treating skin cancer by the use of detailed mapping techniques and onsite microscopic examination of the surgically removed skin. Mohs skin cancer surgery allows for the tissue to be examined during the operation through a microscope to ensure that all of the cancer cells have been removed adequately, and that removal of healthy, cancer-free tissue is minimized. Using the Mohs microscopic surgery technique there is a 95% cure rate. Mohs skin cancer surgery is then followed by careful reconstructive surgery to repair the defect (hole) and to yield an aesthetically pleasing result.

Physicians trained in the Mohs surgical technique have specialized skills in dermatology, dermatologic surgery, dermatopathology and Mohs surgery. Additionally, a Mohs surgeon must have the required surgical and laboratory facilities and be supported by a well-trained Mohs nursing and histotechnological staff.